How to take glucosamine Glucosamine - let the joints stay young! Traditional Chinese Medicine

Pharmaceutical drug Glucosamine refers to medical products that fight diseases such as arthritis, osteochondrosis and arthrosis. Also, thanks to the use of Glucosamine, cartilage is formed and a layer is formed between the ends of the bones that rub against each other.

The component of the drug (active active ingredient) is glucosamine sulfate. It is a salt of the natural amino-monosaccharide glucosamine, an analogue of endogenous glucosamine. This compound takes part in the normal synthesis of cartilage connective tissues.

Glucosamine promotes the production of hyaluronic acid and other substances that make up the synovial fluid, articular membranes and cartilage. The mechanism of action of glucosamine sulfate is the stimulation of the production of glycosaminoglycans and, accordingly, articular proteoglycans.

Actually, the substance glucosamine itself is present in small amounts in the human body in its natural form. It is produced as a result of physiological processes occurring in the body, and contributes to an increase in the extensibility of cartilage tissues. In addition, glucosamine exhibits the effect of a natural immunomodulator.

The course intake of the drug Glucosamine promotes the fixation of sulfur in the process of synthesis of chondroitinsulfuric acid, facilitates the normal deposition of calcium in bone tissue, inhibits the development of degenerative processes in the joints, restores their function and reduces pain.

The drug is available in the form of tablets, capsules, a solution intended for intramuscular injection, and a powder for preparing a solution for oral use.

1 coated tablet, Glucosamine contains: glucosamine sulfate - 750 mg.

1 capsule (powder in a gelatin shell) Glucosamine contains: glucosamine sulfate - 750 mg.

1 ampoule 2 ml contains: glucosamine sulfate - 400 mg.

1 sachet of powder for oral solution Glucosamine contains: glucosamine sulfate - 1500 mg.

Indications for use Glucosamine

According to the instructions, the medication is prescribed for the symptomatic treatment of osteoarthritis, arthrosis, osteochondrosis - pain and limited movement of the joints.

Indications for the use of Glucosamine - degenerative-dystrophic diseases of the spine and joints, manifested by the following symptoms:

• patient complaints about loss of sensitivity and crunching in the joints;
• feeling of stiffness in the joints;
• pain in the spine and joints;
• the development of inflammatory processes in the joints;
• inflammation of the tendons;
• injuries and damage to the joints;
• joint pain when walking, squatting, bending over.

Glucosamine for joints is also prescribed for athletes and people who lead an active lifestyle or engage in hard physical labor to protect joints during intense physical exertion and sports.

Instructions for use Glucosamine, dosage

Adults are prescribed to take Glucosamine tablets orally 1.5 g per day once. The course of treatment, as a rule, is 6 weeks, and if necessary, a longer time.

Intramuscular injections (shots)

For an injection, Glucosamine must be prepared - one dosage of the drug is mixed with a solvent and 3 ml of the resulting solution is injected at 400 mg 3 times a week for 4 to 6 weeks, then a break in therapy is taken.

Can be combined with simultaneous oral administration of tablets or capsules.

1-2 tablets or 1-2 capsules of Glucosamine per day, always with meals (mg).

The contents of 1 sachet or sachet (powder for suspension), previously dissolved in a glass of water, are taken 1 time per day with meals (1500 mg). Adult patients with arthrosis and osteoarthritis, as a rule, are prescribed 1 sachet of the drug per day.

The duration of therapy and the dose of Glucosamine is determined by the doctor.

Features of the use of Glucosamine

In the event of drowsiness, fatigue, dizziness, loss of coordination or visual impairment, as a side effect of taking Glucosamine, driving and working with potentially dangerous mechanisms is prohibited.

It is undesirable to use alcoholic beverages simultaneously with Glucosamine, since ethanol reduces the effectiveness of the active substance of the drug.

It is not recommended to take this medicine during pregnancy, since the effect of the active substance on the development and condition of the fetus has not yet been fully studied. For the same reason, it is contraindicated to be treated with Glucosamine during lactation.

A noticeable improvement in the condition of the joints occurs 2 weeks after the start of using the drug orally, and after only 4 days with the injection route of administration (glucosamine injections).

Side effects Glucosamine, contraindications

During the period of therapy with Glucosamine, pain may develop in the epigastric region and the occurrence of side effects such as: stool disorders, flatulence, as well as headache, dizziness, drowsiness, weakness, short-term loss of efficiency and skin hypersensitivity reactions.

Glucosamine sulfate solution for intramuscular administration additionally (due to the content of lidocaine in the composition): vomiting, drowsiness, diplopia, headache, dizziness, numbness of the tongue and oral mucosa, tremor, euphoria, disorientation, impaired cardiac conduction.

Overdose is not described in official sources and is unlikely.

In case of accidental administration of the drug in doses significantly higher than recommended, gastric lavage should be carried out and enterosorbent agents should be prescribed.

Glucosamine is not prescribed to patients with known hypersensitivity to the components that make up the powder or tablets (including lidocaine - for a solution for intramuscular injection).

Glucosamine should not be used in patients with phenylketonuria and severe renal impairment.

In pediatric practice, the drug Glucosamine is used only for the treatment of children over 15 years of age.

Glucosamine analogues, list of drugs

• Aminoartrin;
• Glucosamine sulfate;
• Glucosamine sulfate 750;
• Don;
• Pharmaskin THC;
• Elbon;
• Unium.

Important - instructions for use Glucosamine, price and reviews do not apply to analogues and cannot be used as a guide for the use of drugs of similar composition or action. All therapeutic appointments must be made by a doctor. When replacing Glucosamine with an analogue, it is important to get expert advice, it may be necessary to change the course of therapy, dosages, etc. Do not self-medicate!

The systematic intake of Glucosamine allows you to restore the elasticity of the joints, expand the mode of motor activity and improve the quality of life in the presence of chronic pathologies of the musculoskeletal system. Also, the effect is fixed for a sufficiently long time, after the course of therapy with this drug.

Glucosamine is on the OTC list in pharmacies. Doctors' comments about Glucosamine are mostly positive and are based on the fact that its use allows you to quickly relieve pain symptoms in destructive diseases of cartilage tissues.

Glucosamine

Description current as of 11/14/2014

• Latin name: Glucosamine
• ATX code: M01AX05
• Active ingredient: Glucosamine (Glucosamine)
• Producer: Elit-pharm, Ukraine, Dnepropetrovsk

Compound

The medicine in tablets contains the active substance glucosamine sulfate, and it also contains additional substances.

The powder for preparing the solution contains glucosamine sulfate and additional substances, including the composition of the product includes sorbitol, aspartame.

Release form

The drug is available in the form of coated tablets. The polymer package contains 30, 60, 90 or 100 tablets. Also coated tablets can be packed in blisters of 10, 12 or 15 pcs.

The powder used to prepare the solution is contained in sachets, in a pack of cardboard - 20 sachets.

pharmachologic effect

Preparations with this substance are agents that contribute to the active restoration of the structure of cartilage tissue. The glucosamine sulfate component of the drug is a salt of the natural amino-monosaccharide glucosamine, an analogue of endogenous glucosamine.

Under the influence of the drug, the processes of synthesis of cartilage proteoglycan and glycosaminoglycan are activated, hyaluronic acid is more actively formed in the synovial fluid. The most pronounced anabolic effect of this substance is observed in people who have functional and morphological lesions of the matrix, which are associated with the use of corticosteroids.

The substance inhibits enzymes that destroy cartilage tissue, reduces the activity of superoxide radicals, lysosomal enzymes. As a result, active glucosamine stops the destruction of cartilage tissue, prevents the development of arthrosis and its progress. The agent does not affect the functions of the respiratory, nervous, cardiovascular system.

The level of absorption in the intestine is approximately 90%. The highest concentrations of the substance are observed in the kidneys, liver, articular cartilage. It should be taken into account, when taking glucosamine, that this remedy begins to act (its therapeutic effect is manifested) after taking it for 1-2 weeks. After oral administration, the drug is metabolized and excreted through the kidneys. Bioavailability is 25%.

Indications for use

Before starting treatment, the patient must clearly know what glucosamine is and how it works. The drug is prescribed for the treatment of people who suffer from arthrosis and osteoarthritis of the spine and peripheral joints. In particular, the drug is prescribed in cases where these conditions are accompanied by pain and deterioration of joint mobility.

Contraindications

The following contraindications are defined: Glucosamine should not be prescribed to people with hypersensitivity to the components of the tablets or powder. The drug is not used in the treatment of patients with severe renal impairment and phenylketonuria. Tablets and powder, as well as dietary supplements Glucosamine NSP, Honda Glucosamine, etc. are not used for the treatment of children and adolescents who are under 15 years old.

Side effects

In most cases, the drug is well tolerated. During treatment, pain in the epigastric region, flatulence, and stool disorders are sometimes manifested. Headaches, hypersensitivity of the skin can also periodically appear. Similar side effects can also be observed when taking other drugs that contain this substance, for example, Glucosamine Plus, Dona Glucosamine, Glucosamine Chondroitin Super Formula, etc. If these or other adverse events develop, you should consult a specialist.

Glucosamine, instructions for use (Method and dosage)

The instructions for Glucosamine powder for the preparation of the solution provide that the contents of the package are dissolved in a glass of water immediately before ingestion. For how long the treatment is carried out, the specialist determines.

In the treatment of osteoarthritis and arthrosis, an adult patient should take 1 sachet per day. Treatment, depending on the complexity of the disease, can last from 1 to 3 months. If there is such a need, the course of therapy can be extended. Two months after the end of treatment, a second course of taking the drug or other drugs with the same active ingredient, for example, Dona Glucosamine, is possible.

The medicine in tablets should be taken during meals, while drinking a small amount of liquid. As a rule, in the treatment of adult patients, the drug is prescribed at a dose of 1 tablet per day. The course of treatment can last from 3 to 6 months.

Overdose

In the course of treatment, cases of overdose were not observed. If too high a dose of the drug was taken, you need to wash the stomach and take enterosorbents.

Interaction

The properties of glucosamine sulfate are such that when taken simultaneously with tetracycline drugs, intestinal absorption of drugs can be enhanced.

The drug, when taken simultaneously, reduces the level of absorption of chloramphenicol and penicillins.

The agent enhances the anti-inflammatory and analgesic effect of anti-inflammatory nonsteroidal drugs, and there is also a decrease in the negative effects of corticosteroids on cartilage tissue.

A specialist will help you choose the optimal drug containing glucosamine (Amway remedy, olive glucosamine in capsules, etc.).

Terms of sale

You can buy powder and tablets in a pharmacy by prescription.

Storage conditions

Keep the drug at a temperature of 15 to 30 degrees Celsius.

Best before date

Tablets can be stored for 5 years, powder - 3 years.

special instructions

Before starting treatment with this medicine, or other drugs with glucosamine (Glucosamine CSA super strength, Glucosamine MSM, Glucosamine plus MSM 1500 mg, etc.), you should definitely consult a specialist.

You need to take the remedy every day, a long course of treatment is necessary.

If the patient is obese or is taking diuretics, the dose can be increased.

A good effect in the treatment can be obtained by combined means and the combined use of drugs, for example, Chondroitin Complex, Glucosamine and Chondroitin Sulfate.

In veterinary medicine, the remedy is used for dogs and other animals, but it can only be used after the appointment of a veterinarian.

Glucosamine is found in foods: beef, chicken, cheese, cartilage, but when heated, it is destroyed.

Analogues

Tablet analogues: Artracam, Artromax, Dona, Artiflex, etc. Any of the analogues can be used for treatment only after prior consultation with a specialist.

children

The tool is not assigned to children and adolescents under 15 years of age, as there are no clear data on its safety.

During pregnancy and lactation

It is forbidden to take during the first trimester of pregnancy. At later stages of gestation, the remedy can be used only if the level of its potential benefit exceeds the potential risk to the health of the woman and the unborn child. If necessary, taking the drug during lactation should stop breastfeeding.

Reviews about Glucosamine

Reviews of drugs based on glucosamine often indicate their effectiveness. In particular, it is noted that when taking such drugs, after 1-2 weeks, the severity of pain in the joints decreases in patients. Reviews for Glucosamine Amway and other drugs very rarely contain data on side effects. But some patients note that they did not notice a pronounced effect after the course of treatment.

Also, many patients concluded that treatment with such drugs should be carried out in parallel with physiotherapy procedures. Similar is the opinion of users about other means, in particular reviews of Ellasteng active glucosamine, etc.

Glucosamine price, where to buy

The price of Glucosamine depends on its manufacturer, as well as the number of tablets in the package. You can buy Glucosamine at a pharmacy or order it on the Internet, where you can find out more exactly how much the drug costs. On average, the price of Glucosamine is from 200 rubles per pack.

How to take glucosamine chondroitin

Before starting treatment, it is always necessary to familiarize yourself with the recommendations of the drug (instruction) so that therapy, even with seemingly harmless drugs, brings only a positive effect, avoiding side effects. Complex glucosamine chondroitin: useful for people who want not only to cure a number of diseases, but also to prevent them.

Any diseases of the joints (inflammatory and degenerative) progress when the destruction of the connective tissue, consisting of cartilage cells, is exceeded over its synthesis. Glucosamine and chondroitin are the main protection and strengthening of cartilage, besides its direct components.

Complex glucosamine chondroitin: useful for people who want not only to cure a number of diseases, but also to prevent them

Short description

Complex glucosamine chondroitin is a dietary supplement (BAA), not a drug.

Indicated for use in the treatment and maintenance of joints, connective and cartilage tissues; acts as an anti-inflammatory agent.

Indications

• Inflammation of the tendons of the shoulder
• Deforming arthrosis
• Osteocondritis of the spine
• Fractures of any bone
• Reactive arthritis (arthropathy)

Reactive arthritis can be treated with glucosamine chondroitin

• Spondylosis of the cervical, thoracic or lumbar spine
• Local or general osteoporosis
• Inflammation of the inner lining of the tendon of the muscle
• Bursitis
• Gout (gouty arthritis)
• Rheumatoid and rheumatic arthritis

Indicated for use as a wound healing agent

• Weakness and increased fragility of the nail plates
• Tendency to baldness
• Various diseases of the heart and blood vessels
• Ankylosing spondylitis
• The glucosamine chondroitin complex is used in cosmetology: improving the condition of the skin and overall facial tone, the ability to smooth wrinkles and make them less noticeable, treatment of pigment deposits in the skin (see instructions for use)

Complex glucosamine chondroitin is used in cosmetology

How does it work?

• Glucosamine chondroitin complex promotes healing of injured cartilage tissue
• It has an anti-inflammatory effect, helps to reduce pain and relieve tension in the joints, makes them more mobile, reduces swelling
• Takes part in the formation and improves the trophism of the cartilage tissue of the articular surfaces
• The complex glucosamine chondroitin has a positive effect on the whole osteoarticular system
• Improves the condition of the skin and nails
• Improves the work of the heart and circulatory system, gastrointestinal tract, respiratory and urinary tract

Improves the functioning of the heart

• Recommended for use for a beneficial effect on the metabolism of articular cartilage
• Accelerates the formation and promotes the renewal of the structural parts of cells, tissues and muscle structures
• Slows down the process of metabolic decay
• The glucosamine chondroitin complex promotes the unification of the main components of connective tissues after their damage.
• Reduces the rate of enzymes that break down connective tissues and cartilage
• Microcirculation of the arterial vascular bed

Provides essential lubrication for proper joint function

• The complex glucosamine chondroitin promotes the process of mineralization and development of bone tissue, restores phosphorus-calcium homeostasis and balance
• Helps to reduce the formation of thromboxane A2, which is released from platelets when it is activated; anticoagulant effect
• Accelerates the healing of wounds, trophic and radiation ulcers, the glucosamine chondroitin complex is used to treat long-term non-healing wounds, ulcers, aphthae, erosions, fractures
• Indicated for use to reduce the level of "bad" cholesterol in the blood, resists its deposition in the walls of arteries

Contraindications

• Allergy or individual intolerance to any components of the complex (see instructions for use)
• The drug should not be taken during pregnancy and lactation; if the use of the drug is indispensable during lactation, it is necessary to consult the attending physician

• Not suitable for children under 15 years of age
• The drug is contraindicated in people with renal insufficiency, phenylpyruvic oligophrenia, as well as people with a pronounced tendency to bleeding

Side effects

According to research data, the drug is well tolerated, in rare cases it is possible: from the gastrointestinal tract (nausea, vomiting, diarrhea or constipation, epigastralgia), neurology (dizziness), allergology (skin rash accompanied by itching).

Doses and methods of application

The biologically active additive is intended for oral administration (by mouth). Gelatin capsules must be swallowed completely and should not be chewed or crushed. Drink only water, in plenty. The drug is taken half an hour before meals.

The biologically active additive is intended for oral administration

For children over 15 years of age and adults, the glucosamine chondroitin complex is usually prescribed to take 1 capsule twice a day for three weeks.

After that, you should switch to 1 capsule once a day to maintain the effect.

The duration of therapy in most cases is at least two months, but in order to achieve a lasting result, the complex should be taken for at least 6 months.

People who are treated with the glucosamine chondroitin complex should not drink drinks containing alcohol and excessive amounts of sugar.

Glucosamine instructions for use, composition, indications, analogues and reviews

The drug Glucosamine refers to medicines that fight diseases such as arthritis. Also, thanks to the use of Glucosamine, cartilage is formed and a layer is formed between the ends of the bones that rub against each other.

Composition and form of release

Glucosamine is available in both powder and tablets.

• One sachet contains 1885 mg glucosamine sulfate sodium chloride or 1500 mg glucosamine sulfate. Additional substances: aspartame, sorbitol, anhydrous citric acid and macrogol 4000.
• One tablet contains: glucosamine phosphate (373.4 mg) and chondroitin sulfate sodium (195.7 mg). Additional substances: dicalcium phosphate, sodium starch glycolate, magnesium stearate, silicon dioxide.

Glucosamine - instructions for use in various dosage forms

This drug Glucosamine is able to protect and strengthen the joints, as well as eliminate pain and relieve stiffness (which leads to degenerative changes in the joints). According to scientists, many people know that the body itself is able to produce Glucosamine in small quantities. Glucosamine is a chemical compound that is made up of glucose. In the body, it is found in the joints, as well as in connective tissues, where it then forms larger molecules that form and repair cartilage.

Glucosamine: application in the form of tablets

For adults and children over 14 years of age, Glucosamine should be taken one tablet 3 times a day with meals. The maximum effect is achieved after 2-8 weeks of use. In order for the effect to be preserved and strengthened, the duration of the drug is extended to 3 months.

Application of Glucosamine Powder

The instructions for Glucosamine say that this drug should be taken orally inside. For adults and children over 14 years of age, Glucosamine should be taken 1 sachet per day with meals. Before use, the sachet must be dissolved in a glass of water. The duration of such treatment can range from 4 to 12 weeks (or longer).

According to the doctor's prescription, the course can be repeated with a break of 2 months. Glucosamine does not cure acute pain symptoms - everyone needs to know this. The maximum effect is achieved after 2 weeks of use, and in some cases even later. If the symptoms do not go away after two or three months of treatment, then the course of treatment should be reconsidered.

How to use it correctly: Glucosamine regimen

Before starting treatment with Glucosamine, the patient should definitely consult a doctor in order to exclude those joint diseases that require more serious treatment. Patients who have lower glucose levels or who are potentially in need of insulin should be treated under the strict supervision of a doctor.

Patients who have a disease such as bronchial asthma should be wary of Glucosamine. Since such people are most susceptible to various allergic reactions to drugs. And because of such side effects, there may be an opposite effect from the use - an exacerbation of symptoms.

The drug contains sorbitol, so those patients who have a rare form of fructose intolerance cannot use this drug. Also, 1 sachet contains 6.6 mmol of sodium. Therefore, those patients who control the amount of sodium entering the body should use Glucosamine with caution.

People with diabetes should have their blood sugar checked before using this drug. The drug should be used under the strict supervision of a physician in cases where patients have impaired liver and kidney function.

Indications, contraindications and side effects of Glucosamine

Like any other drug, Glucosamine also has its indications, contraindications and side effects.

Indications for the use of Glucosamine

• arthrosis;
• Osteoarthritis of the spine and peripheral joints.

Before starting treatment, you need to familiarize yourself with the constituent parts of the drug and find out how it works. Glucosamine is also prescribed for pain and deterioration of joint mobility.

Contraindications for the use of Glucosamine

• Do not use this drug for people who are hypersensitive to any of the components of the tablets or powder;
• Do not use Glucosamine for people who have severe disorders of the liver and kidneys;
• Also, this drug should not be used in children under 14 years of age.

• The most common side effects include nausea, abdominal pain, gastrointestinal problems, constipation, and diarrhea;
• There may also be symptoms such as headache, fatigue, rash, redness after taking the remedy;
• From the nervous system: headache, drowsiness, dizziness;
• From the gastrointestinal tract: nausea, abdominal pain, indigestion, constipation, diarrhea, flatulence, dyspepsia;
• From the immune system: various allergic reactions of the body;
• On the part of the organs of vision: blurred vision (very rarely);
• From the skin and subcutaneous tissue: rash, scabies, erythema, urticaria, hair loss.

Can Glucosamine be taken during pregnancy?

During pregnancy, you should refrain from using any medications. But cases, as they say, are different. The medicine should not be used in the first trimester of pregnancy. In the second and third trimester, Glucosamine is prescribed only in cases where the benefit to the mother outweighs the potential risk to the fetus. During lactation, this drug should also not be used. And if the doctor has already prescribed the use of the drug, then you need to think about stopping breastfeeding.

The use of Glucosamine for children

The medicine should not be used in children under 14 years of age. No research has been done on this, unfortunately.

Medicinal effect of the drug Glucosamine

Medicine has come a long way in the last few decades. And now Glucosamine can be seen in almost any pharmacy as a dietary supplement. There are different forms of the remedy, so before using it, you should definitely consult a doctor so that he advises you to choose the right option.

The medicine helps to cope with rheumatoid ratitis and other joint lesions. Thanks to this drug, the range of motion increases and aging and damaged knee, hip joints, as well as joints of the spine and joints of the hands are restored. Many studies show that Glucosamine copes with pain much better than other drugs called aspirin, ibuprofen and other non-steroidal anti-inflammatory drugs. It is also good that the remedy has no side effects when applied.

Drugs that simply relieve joint pain do not cure, but only hide the cause, thereby worsening the overall health of a person. Therefore, Glucosamine is considered one of the most effective means in the fight against arthritis. It helps to form and repair affected joints.

Of course, in advanced conditions, this Glucosamine will not be very effective, but in the initial stages of arthritis, it will undoubtedly help.

Interaction of Glucosamine with other drugs

As mentioned above, the drug contains glucosamine sulfate, so if it is used together with other drugs of the tetracycline group, then the intestinal absorption of drugs can only increase. When taken simultaneously, the level of absorption of substances such as chloramphenicol and penicillin also decreases.

With the simultaneous use of the drug with anti-inflammatory nonsteroidal drugs, the anti-inflammatory and analgesic effects are enhanced. The negative effect of corticosteroids is reduced on cartilage tissue. Before using Glucosamine with other drugs, you should definitely consult a doctor.

Glucosamine analogs

Like most drugs, Glucosamine also has its analogues:

Means analogue - Aminoartrin

This drug helps prevent the destruction of cartilage, as well as stimulate the restoration of cartilage compounds (tissues). Aminoartrin has anti-inflammatory and analgesic effects. It is also Glucosamine - an excellent tool for normalizing the production of intra-articular fluid. Thanks to the use of Aminoartrin, joint mobility improves;

Means analog - Sustilak

This Glucosamine affects the metabolism in cartilage compounds (tissues). Sustilak helps to avoid the natural deficiency of glucosamine, as well as increase the permeability of the joint (joint capsule). Thanks to this drug, the restoration of enzymatic processes in the cells of the articular cartilage is much faster. Calcium is debugged in bone tissue easily. Also, thanks to Sustilak, degenerative processes in the joints do not develop. Joint pain is reduced;

Glucosamine analogue - Chondroxide Maximum

The main active ingredient of this drug is glucosamine sulfate. Thanks to it, the synthesis of hyaluronic acid and proteoglycans is stimulated. Chondroxide Maximum restores the cartilaginous surfaces of the joints of the spine, as well as peripheral joints. This drug has an anti-inflammatory and analgesic effect on the body. Joint pain is significantly reduced;

Yunium - analogue means

This drug helps prevent the destruction of cartilage, as well as stimulate the restoration of cartilage compounds (tissues). Aminoartrin has anti-inflammatory and analgesic effects. It is also Glucosamine - an excellent tool for normalizing the production of intra-articular fluid. Thanks to Aminoartrin, joint mobility improves.

The price of the drug in pharmacies

Check out the price of Glucosamine in 2018 and cheap analogues >>> The cost of Glucosamine in different pharmacies can vary significantly. This is due to the use of cheaper components in the drug, and the pricing policy of the pharmacy chain. But the important thing is that the difference in price between foreign and Russian counterparts remains virtually unchanged.

Glucosamine - instructions for use, release forms. List of analogues of Glucosamine, prices

Latin name: Glucosaminum

International name: Glucosamine

Active ingredient: Glucosamine sulfate

Producer: Elit-pharm, Ukraine

Pharmacy dispensing condition: By prescription

Compound

The drug includes the main active ingredient - glucosamine sulfate, it is available in two dosage forms: tablets and powder.

Medicinal properties

The drug, acting on tissues, activates the production of proteoglycan, as well as cartilage glycosaminoglycan. Thanks to taking the drug, the production of hyaluronic acid improves, which is one of the components of the synovial fluid. It has a clear anabolic effect on the body of those people who suffer from functional or morphological pathologies of the matrix, provoked by the use of corticosteroids.

The drug inhibits the synthesis of enzymes that damage cartilage, reduces the impact of superoxide radicals, as well as enzymes released during phagocytosis and lysis. As a result, the process of destruction of cartilage tissue slows down, which reduces the likelihood of the development and progression of arthrosis. That is why Glucosamine is needed to prevent diseases of the musculoskeletal system.

It is very important that the drug does not have a negative effect on the central nervous system, cardiovascular system and respiratory system, while being a synthetic analogue of glucosamine hydrochloride.

Pharmacokinetics and pharmacodynamics

The process of absorption of the components of the drug mainly takes place in the intestine. The highest concentration of glucosamine sulfate is observed in the tissues of the liver and kidneys, as well as directly in the articular cartilage.

It is worth noting that it does not act immediately, a quick effect on the body should not be expected, the therapeutic effect occurs within 1-2 weeks from the moment of its application.

The dietary supplement is excreted by the kidneys, its bioavailability is 25%.

Indications for use

• Osteoarthritis of different localization, as well as osteochondrosis
• Periarthritis of the scapular-elbow joints
• Arthrosis
• Chondromalacia patella
• Progressive spondylosis.

Tablets "Glucosamine"

Price from 362 to 688 rubles.

Each tablet contains the main active ingredient and an auxiliary component - ascorbic acid.

Coated tablets are available in carton packs of 30, 60, 90 or 100 tab. The blister contains 10, 12 or 15 tablets.

Price from 362 to 688 rubles.

Dosage and administration

The best time to take the tablets is with food and water. The recommended dose for children over 15 years of age, as well as adults - from 1 to 2 tablets, which is from 750 to 1500 mg of the active substance per day.

Duration of treatment - from 4 months to six months. The passage of a second course of therapy is possible after 2 months.

Powder "Glucosamine"

The average price is 990 rubles.

The powder from which the suspension is prepared is intended for oral administration. It contains glucosamine sulfate and auxiliary components - sweeteners: aspartame, as well as sorbitol.

The powder is packaged in sachets. Each drug pack contains 20 sachets.

Dosage and administration

The suspension is prepared by mixing the contents of 1 sachet with 200 ml of water. The use of the resulting solution should be combined with food intake.

You can also take the suspension immediately after a meal. The recommended daily dose is 1500 mg glucosamine (1 sachet).

The duration of therapeutic therapy is 1-4 months. If the symptoms of the disease have not completely disappeared, it is possible to extend the course of treatment up to six months.

It is necessary to observe a two-month break between the previous and subsequent course of treatment.

Contraindications

You should not take the drug if you have the following symptoms and diseases:

• Excessive sensitivity to the main component of the dietary supplement
• Kidney pathologists
• Fineketonuria
• Children's age up to 15 years.

During pregnancy and breastfeeding

To date, there is no information on how dietary supplements affect the body of a pregnant woman and the fetus. The effect of the drug on the child during breastfeeding has not been thoroughly studied, so it is better not to take it during this period.

Precautionary measures

During the course of treatment with the drug, it is worth limiting the use of sugar-containing foods, refuse to take alcoholic beverages, since in this case it can contribute to the development of side effects.

Interaction with other drugs

It should be borne in mind that it is undesirable to combine dietary supplements with drugs of the tetracycline group, since there is an increased absorption of drugs in the gastrointestinal tract. It reduces the bioavailability of chloramphenicol, as well as penicillin drugs.

With the simultaneous use of non-steroidal anti-inflammatory drugs, the effect of the latter increases, the negative effect of corticosteroids on cartilage tissue decreases.

Side effects

Often, dietary supplements can negatively affect the work of the gastrointestinal tract, resulting in a feeling of heaviness in the epigastric region, flatulence and diarrhea develop. It can cause nausea and allergic manifestations on the skin. With the development of an adverse reaction, it is better to stop the drug. Ways to quickly eliminate diarrhea are described in the article: treatment of diarrhea.

Overdose

During the treatment with the drug, cases of overdose in patients were not detected. If dietary supplements were taken in a dosage exceeding the daily one, gastric lavage should be carried out, enterosorbents should be started.

Terms and conditions of storage

Analogues

The pharmaceutical market offers a number of analogues of Glucosamine, both domestic and foreign.

"Glucosamine hydrochoride"

STC ECOBIOTEK, Russia

The average price is 270 rubles.

The drug is a powder with the active ingredient glucosamine hydrochloride. Corrects metabolic processes in bone and cartilage tissue.

• Promotes increased permeability of the joint capsule
• Glucosamine hydrochoride reduces pain
• Suspends degenerative processes occurring in the joints.

• Glucosamine hydrochoride is hard to find in pharmacies
• Reception is not recommended for impaired atrioventricular conduction.

"Chondroitin - AKOS"

"Chondroitin-Akos" is an analogue of Glucosamine in terms of the mode of action. The drug is produced in the form of capsules, the active ingredient of which is sodium chondroitin sulfate. As a result of its action, the strength of painful sensations decreases, the mobility of the joints increases significantly. Chondroitin sulfate sodium helps to reduce calcium loss in cartilage tissues.

• Low cost
• Chondroitin sulfate sodium slows down the progression of osteoarthritis.

• Not intended for children under 18 years of age
• Chondroitin sulfate sodium may cause gastrointestinal side effects.

"Glucosamine NSP"

Nature's Sunshine Products, USA

Available in the form of capsules, contains glucosamine and cat's claw. The dietary supplement promotes the restoration of cartilage tissue, strengthens ligaments, takes part in the synthesis of collagen.

• Protects cartilage
• Improves the condition of nails, hair and skin.

• Expensive
• It is not prescribed during pregnancy and lactation.

"Glucosamine Chondroitin Complex"

Glucosamine Chondroitin complex is presented in a convenient dosage form - capsules. The composition of this dietary supplement includes glucosamine sulfate and sodium chondroitin sulfate, which support joint health, restore cartilage tissue, and relieve inflammation.

• Affordable price
• High efficiency
• Ease of use.

• The need for long-term use of Glucosamine Chondroitin Complex
• Low concentration of the active substance.

Taking Glucosamine Medication

Glucosamine is a unique medicine that can restore destroyed cartilage tissue. The composition of the drug includes the substance Glucosamine sulfate, which has a positive effect on the patient's recovery. We will tell you how to take the drug correctly, what contraindications and side effects it has. You will also get acquainted with real patient reviews and find out the average cost of a medicine.

Indications for the use of the drug

Doctors prescribe Glucosamine for patients with osteochondrosis and osteoarthritis of the spine. If at the time of illness a person has severe back pain and joint mobility disappears, then treatment with Glucosamine is mandatory. It must be taken in combination with other means and procedures. Then the therapy of osteochondrosis will quickly give a positive result.

How to apply the medicine correctly?

You can treat osteochondrosis with an oral solution of Glucosamine. It must be dissolved in one glass of clean water. It is required to use the medicine at the time of the meal in order to achieve the best result. The daily dose of the powder should be determined by the attending physician according to the diagnosis of the patient.

Most often, adults with osteochondrosis are prescribed one sachet of Glucosamine per day. The course of treatment lasts from 4 to 10 weeks, depending on the stage of the disease. If osteochondrosis is not completely cured, then the doctor may extend therapy. A second course is allowed after 2 months.

You can also take Glucosamine tablets. They should be consumed at the time of the meal and washed down with a glass of water. Most often, patients are prescribed 1 tablet of Glucosamine per day. Therapy lasts from 3 months to six months. The dose of the drug is prescribed by the attending physician after a complete diagnosis.

Side effects of the drug

Doctors noted that with the correct intake of Glucosamine, patients do not suffer from negative side effects. However, it is necessary to highlight some of them that may occur with the wrong dosage:

• It is difficult for patients to go to the toilet;
• Unpleasant pain in the epigastric region;
• Flatulence;
• Severe pain in the head, migraine;
• Allergic reaction.

Contraindications to taking the drug

It is important to know when Glucosamine is forbidden to be taken so as not to harm health. Be careful in these situations:

1. Dangerous for patients with allergies to the composition of the drug;
2. Prohibited for patients with phenylketonuria and kidney disorders;
3. Do not use for the treatment of children under 15 years of age.

Use of medication during pregnancy

Doctors forbid taking Glucosamine from the first trimester of pregnancy. It must be remembered that the appointment of the drug in the 2nd and 3rd trimester can only be a last resort. It is necessary to carefully consider the risks for the unborn fetus and understand whether the drug will bring the proper benefit to the mother.

If the doctor has prescribed Glucosamine at the time of lactation, then you should immediately stop breastfeeding. Indeed, otherwise, the substances of the drug through the milk will enter the body of the baby and can cause complications.

Interaction with other drugs

You need to know which medications should not be taken in parallel with Glucosamine. After all, it can enhance or weaken the effect of certain drugs.

• Glucosamine will enhance the effect of tetracycline group drugs for the intestines;
• The drug will reduce the effects of chloramphenicol and penicillin antibiotics;
• Glucosamine will reduce the negative effect of corticosteroids on damaged cartilage tissue.

Overdose

Doctors did not notice significant complications after taking too much Glucosamine. However, if you still exceeded the allowable limit, tell your doctor right away. He will be able to do a gastric lavage in time and prescribe special enterosorbent medications. Thus, you reduce the risks to the body to a minimum.

Release form of the drug

Now you can buy Glucosamine in the pharmacy in the following forms:

1. Tablets. Sold in a polymer bottle, which is packed in a cardboard box;
2. Tablets. Sold in a small blister pack. Usually in one cardboard pack there are 5 such records;
3. Powder Glucosamine in a sachet. One box contains 20 sachets.

Rules for storing the drug

You need to store the medicine at room temperature - degrees. The shelf life of Glucosamine is no more than 5 years. The powder can be stored for no more than 3 years. Try to keep the drug away from small children.

The composition of the medicine

One tablet contains 750 mg of Glucosamine sulfate. In addition, there are additional ingredients in the medicine. One sachet contains 1500 mg Glucosamine sulfate. In addition, the composition includes sorbitol and aspartame.

Average drug price

The drug Glucosamine can be bought at every pharmacy at the following average prices:

1. Glucosamine complex - 90 pieces for 430 rubles;
2. Glucosamine capsules - 60 pieces for 350 rubles;
3. Glucosamine Maximum in tablets - 60 pieces for 560 rubles;
4. Glucosamine powder - 1 pack for 400 rubles;
5. Glucosamine Maximum in tablets - 30 pieces for 380 rubles.

Drug analogues

Doctors may prescribe a drug similar to Glucosamine, which has a similar composition and spectrum of action. Let's highlight a few similar drugs.

Glucosamine is a substance whose action is aimed at preventing inflammatory processes in the joints and cartilage, prolonging active life. Animal studies have shown that it helps to significantly increase the average maximum lifespan in mice, rats, nematodes and flies. Its use in humans slows down the aging of the joints.

What is glucosamine?

Glucosamine is a natural substance found in the joints and cartilage of mammals. It was first discovered in 1876 by the German surgeon George Ledderhouse. It consists of the most important monosaccharides and amino acids for the body - glucose and glutamine.

Cartilage cells use glucosamine as an intermediate for the production of hyaluronic acid, proteoglycans, and glycosaminoglycans. Since the 60s of the last century, scientists have decided to use the substance to restore cartilage and joints, and treat arthrosis. Large-scale studies began, the results of which were inconsistent.

Conducted in 2002-2006, studies in America confirmed the absence of a therapeutic effect in the treatment of arthrosis. The substance was given the title of "ambiguous" for questionable pain-relieving properties. Doctors recommend that you stop taking it if the expected effect has not occurred within 6 months after the start of taking the substance.



Release form

The dietary supplement is available in the form of tablets or powder for solution preparation. The second option is more preferable, as it works faster.

The powder is packed in sealed bags of 3.5 g; 20 pieces in a box. Each sachet contains 1.5 g of the active substance.

Taking a supplement will only have an effect if you strictly follow the recommendations of your doctor. The dosages indicated in the instructions are strictly observed, unless otherwise provided by the doctor. Self-medication is unacceptable.

Compound

Any form of the drug contains the main active ingredient - glucosamine sulfate. Auxiliary components: sorbitol, aspartame, etc. They provide good absorption of the main active substance by the body.

Pharmacological action and pharmacokinetics

Glucosamine helps cartilage tissues cope with structural disorders and age-related changes, promotes the restoration of joints and cartilage.

Approximately 90% of the substance is absorbed in the intestine, while the highest concentration of the active ingredient is found in the kidneys, ligaments and liver. The withdrawal of funds from the body occurs with the help of the kidneys and urinary system. The use of bioadditives does not affect the functional features of the cardiovascular, respiratory and nervous systems.

Indications for use

As a rule, the main indication for the use of the supplement is joint pain, loss of normal mobility.

Contraindications

Contraindications are usually associated with the following factors:

• propensity to allergies;
• individual intolerance to the components;
• serious pathologies of the kidneys;
• phenylketonuria.

Glucosamine should not be taken by children under the age of 15.

Pregnancy and lactation

In the first trimester of pregnancy, the drug is strictly prohibited for use by women. In II and III, admission is possible only if the potential benefits for the girl will exceed the risks for the baby.

The active substances of the drug pass into breast milk. It can be taken during lactation, but breastfeeding should be stopped for the duration of treatment.

Dosage and administration

The powder solution is diluted in a glass of clean water. Take one sachet daily. An individual treatment regimen is prescribed by a doctor, usually therapy takes at least 1-3 months, depending on the severity of the disease. A second course is possible two months after the first. Treatment with the drug is usually quite long and the first improvements occur at best after 1-2 weeks from the start of treatment.

In the form of tablets, the medicine is taken with food, drinking plenty of water. The dosage is determined by the attending physician. Usually adult patients are prescribed 1 capsule once a day. The duration of therapy can vary from 3 to 6 months.

Side effects and overdose

In the vast majority of cases, the drug is well absorbed and tolerated by the body. However, unpleasant side reactions occur in the form of gastrointestinal disorders, headaches, dizziness and increased skin sensitivity. If you experience any reaction, you should consult your doctor.

For the entire period of use of supplements, not a single case of overdose has been identified. In case of unpleasant reactions after taking the remedy, it is necessary to wash the stomach and take enterosorbents. Then see a doctor.

Interaction with other drugs and precautions

When used simultaneously with tetracycline drugs, glucosamine promotes their accelerated absorption. The reverse situation is observed with penicillins and chloramphencol, their digestibility, on the contrary, slows down. The effect of taking anti-inflammatory non-steroidal drugs is significantly enhanced, and the harmful effects of corticosteroids on cartilage tissue are reduced.

It is important to consult with your doctor before taking the medication. For people suffering from obesity, the dosage is increased to achieve a therapeutic effect. Long-term use of the drug is required.

Storage conditions and shelf life

Store the product out of the reach of children, avoiding sunlight. The temperature in the room should be within + 15- + 30 degrees.

You can store the tablets for 5 years, and the powder for the preparation of the solution - 3 years.

Terms of dispensing from pharmacies

The product is sold only by prescription.

Analogues in Russia, USA and Europe

Only the attending physician will help you choose a medicine with a similar or similar composition. The most popular today are Artrakam, Dona, Artiflex, Elbona, Union and others.

The modern pharmaceutical industry offers various forms of preparations based on glucosamine sulfate. In European countries, glucosamine has the status of a drug, and in the US, a dietary supplement. It is noteworthy that in American dietary supplements the concentration of the substance is higher than in European medicines.

Means based on glucosamine have been studied for more than a decade. Many scientists and doctors consider the results of treatment with this substance controversial. We can say for sure that it really works, but the price of supplements with it is often unreasonably high.

Nature "s Bounty, Inc. Sante Naturelle (A.G.) Ltee. Solgar Vitamin and Herb VNESHTORG PHARMA, LLC INAT-PHARMA, LLC MARBIOPHARM LLC PHARMACOR PRODUCTION PHARMACOR PRODUCTION LLC H.ten Herkel B.V./Natur Produkt Europe B.V. Herkel B.V. Evalar ZAO Unipharm Inc.

Country of origin

Netherlands Poland Russia UNITED STATES USA

Product group

Other dietary supplements for internal use

Biologically active additive (BAA) to food

Release form

• 120 tabs in a jar 14 sachets in a carton box 30 tabs in a pack 60 tabs in a jar pack 60 tabs 90 capsules in a polyethylene jar Powder for solution for oral administration 1500 mg. 4 g of powder in heat-sealed bags - 20 bags, together with instructions for use, are placed in a cardboard package (pack). tablets weighing 1400 mg - 30 pieces per pack. pack 20 sachets pack 60 caps pack 60 tabs pack 75 tabs

Description of the dosage form

• white or white with a yellowish tint granular powder. capsules powder powder weighing 10 g in a sachet in a pack of cardboard tablets tablets weighing 1254 mg Coated tablets effervescent tablets

pharmachologic effect

Glucosamine Maximum is a combination of glucosamine and chondroitin, which have been used by doctors all over the world for many years for the prevention and complex treatment of diseases of the musculoskeletal system, including osteoarthritis. Glucosamine and chondroitin are natural components of articular cartilage that are necessary for the normal synthesis of cartilage connective tissue and help prevent cartilage destruction. The interaction of these components and the high content of the active substance provide a pronounced and stable beneficial effect on the joints and spine. The action of the components contributes to: - a decrease in the intensity of inflammatory processes - a decrease in pain syndrome - the restoration of cartilage and bones - an improvement in joint mobility - an increase in the effectiveness of basic therapy Glucosamine-Maximum helps maintain flexibility and prevent premature aging of the joints. Glucosamine Maximum can be used at the first signs of a violation of the musculoskeletal system, as well as for those who are at risk for the prevention of diseases. Glucosamine Maximum is a reliable basis for the constructive prevention of diseases of the musculoskeletal system and a necessary component of the daily diet of people suffering from diseases of the joints and spine.

Pharmacokinetics

Absorption in the gastrointestinal tract 90%, bioavailability 25%, half-life - 70 hours.

Special conditions

It is not recommended to take children under 12 years of age due to the lack of scientific data for this category of patients. The risk of allergic reactions increases with intolerance to seafood. When using the drug in patients with impaired glucose tolerance, with severe hepatic and renal insufficiency, medical supervision is necessary. Influence on the ability to drive vehicles, mechanisms None.

Compound

• carrier dextrose monohydrate; glucosamine hydrochloride collagen hmdoalieovamny; chondroitin sulfate sodium, ascorbic acid; acidity regulator: citric acid (E33O); natural food flavoring: pineapple (dextrose, maltodextrin gum arabic, natural aromatic substances, aromatic substances), anti-caking agent: amorphous silicon dioxide (E551), sodium hyaluronate; quercetin; sweetener: stevioid (E960), manganese sulfate; sodium selenite. 1 sachet contains: Glucoeamine hydrochloride 1500 mg Chondroitin sulfate 1200 mg Vitamin C 500 mg Hyaluronic acid 50 mg Quercetin 30 mg Manganese 2 mg Selenium 0.07 mg Active ingredients Per 1 tablet Glucosamine -750 mg Chondroitin sulfate -600 mg Rose hips powder -50 .16 mg Glucosamine 200 mg. Chondroitin sulfate 100 mg. Lactose 20 mg. Glucosamine hydrochloride, calcium carbonate, ascorbic acid, chondroitin sulfate, collagen, citrus flavonoids, cholecalciferol, magnesium stearate, silicon dioxide, manganese sulfate, vegetable cellulose. capsule (daily intake) contains: Glucosamine hydrochloride, 500 mg chondroitin sulfate 100 mg ascorbic acid 100 mg calcium 66.7 mg vitamin D3 1.25 µg magnesium 1.7 mg flavonoids 100 mg glucosamine sulfate 1.5 g; Auxiliary substances: aspartame, sorbitol, macrogol-4000/polyethylene glycol-4000/, citric acid monohydrate glucosamine sulfate 750 mg; chondroitin sulfate 250mg; carrier: microcrystalline cellulose; glucosamine hydrochloride; chondroitin sulfate sodium; carrier hydroxypropyl methylcellulose; anti-caking agent: silicon dioxide amorphous; carrier: stearic acid; carrier: maltodextrin, anti-caking agent: talc; dye: titanium dioxide; carrier: croscaramellose sodium; humectant propylene glycol; dye: E102; dye: E133. Glucosamine sulfate 750mg; chondroitin sulfate 250mg; Auxiliary in-va: MCC, calcium carbonate, stearic acid, hydroxypropyl methylcellulose, silicon dioxide, sodium carboxymethylcellulose, glycerin, carnauba wax glucosamine sulfate (from shellfish), sodium chondroitin sulfate, cellulose, vitamin C, MCC, silicon dioxide, magnesium stearate, calcium, stearic acid, glycerin, manganese, glucosamine g/h from shellfish 750mg, sodium chondroitin sulfate 600mg, methylsulfonylmethane 350mg; Auxiliary substances: cellulose, stearic acid, silicon dioxide, magnesium stearate, glycerin Glucosamine sulfate potassium chloride in terms of glucosamine sulfate - 750 mg Excipients: calcium carbonate, microcrystalline cellulose, stearic acid, colloidal silicon dioxide, magnesium stearate, croscarmellose sodium

Glucosamine indications for use

• GLUCOZAMINE MAXIMUM VIAVIT (ViaVit) Helps to improve the condition of the musculoskeletal system in: Processes of cartilage destruction Pain in the joints and spine Supports normal joint mobility Helps with stiffness in movements and crunching of the joints Promotes restoration, nourishes and protects cartilage tissue

Glucosamine contraindications

• Individual intolerance, severe renal dysfunction, pregnancy, lactation. There are no data on the use of the drug in children. With caution: bronchial asthma, diabetes, intolerance to seafood (shrimp, shellfish).

Glucosamine dosage

• 1470 mg 750 mg

Glucosamine side effects

• Dysfunction of the gastrointestinal tract (pain in the epigastrium, flatulence, diarrhea, constipation, nausea), skin allergic reactions (urticaria, skin itching, erythema), from the nervous system (headache, drowsiness).

drug interaction

Increases the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins, chloramphenicol. Enhances the effect of coumarin anticoagulants. The drug is compatible with paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticosteroids. When combined with NSAIDs, it enhances the anti-inflammatory and analgesic effect of the latter.

Overdose

Symptoms: cases of overdose are unknown. Treatment: gastric lavage, symptomatic therapy.

Storage conditions

• store in a dry place
• keep away from children
• store in a place protected from light

Information provided

Many people know the drug for the treatment of the musculoskeletal system glucosamine sulfate . However, in a study on aged mice, it was shown that glucosamine sulfate increased the Average Life Span of mice by 10%,

and even slightly increased their Maximum Lifespan. And this means that even if you start using glucosamine sulfate in old age, when it is already too late to take many medicines, the Average Life Expectancy is still growing.

The material in this article is for illustrative and educational purposes only and is not warranted for any medical use. For more information, please contact your doctor.

And what glucosamine sulfate shows in human studies? As you know, the main ones are (about 40%), cardiovascular diseases (about 50%), colds, in view of, and others. So. Glucosamine sulfate showed in humans a reduction in mortality from cancer by 13%, from respiratory diseases by 41%. And cancerous tumors and respiratory diseases are a sign of the old age of the immune system, as a result of which general inflammation occurs throughout the body. It is assumed that glucosamine sulfate reduces inflammation due to inhibition (containment) of the nuclear factor, as well as due to imitation, as the most reliable means of prolonging life. The nF-kB factor controls the functioning of the immune system and the self-destruction of cancerous tumors. If its work is disturbed, autoimmune diseases occur - signs of aging immunity (lupus erythematosus, psoriasis, autoimmune anemia, allergies, etc.), as well as viral infections are difficult to tolerate, various forms of cancer occur.

Scientific Credibility: Life Extension Research in Aged Mice http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988823/

As can be seen from the graph, if at week 135 40% of mice using glucosamine sulfate (red group of dots) were still alive, only 20% of mice survived in the control group.

In another study on elderly people from the US and Europe (www.ncbi.nlm.nih.gov/pmc/articles/PMC4342228) reduction in mortality from cancer and from respiratory diseases. In a human study, glucosamine has been shown to reduce mortality from cancer (13%), respiratory disease (41%), and other causes (33%). The proposed mechanism of action is the suppression of inflammation through inhibition of the nuclear factor nF-kB, as well as the imitation of a diet with a low glycemic load. It is recommended to take 1500 mg of glucosamine sulfate once a day. 2-3 months course, a month break.

• ajcn.nutrition.org/content/91/6/1791

• www.ncbi.nlm.nih.gov/pmc/articles/PMC3901559/

• www.ncbi.nlm.nih.gov/pubmed/24714520

1. How to stop human aging

Maria

Svetlana, can this help? There is an example of the treatment of my friend. video in the link youtube.com/watch?v=C7n8RtX0CFQ&feature=youtu.be&fbclid=IwAR32wQT7QdkDO8wNhguM0_31oQDmgzAvRJyv_4L4zhm6w4dINhF7k0LOMTI

1. Dmitry Veremeenko

margarita

Good evening! C reactive protein 2 how to reduce? Do you drink glucosamine? P.s. I don't have a cold, I don't get sick.

1. Dmitry Veremeenko

   find out the reason

Evgeniy

Is it possible to combine metformin and glucosamine?
If not, why not?

1. Dmitry Veremeenko

   It is forbidden. Their combination has not been tested in studies. Both are mitohormetins. Mitopoisoning will be possible together

Julia

Dmitry, hello! Can I drink glucosamine with a HOMA-IR index of 1.4 (fasting glucose 5.1, insulin 6.2)? (doubts, because according to the Open Longevity norm<= 1,4)

1. Dmitry Veremeenko

   Listen to the algorithm

Larisa A.

In the instructions for the drug Dona (glucosamine sulfate, Germany) I read the following: “Studies have shown that the drug DONA® has no effect on blood sugar levels in both healthy individuals and patients with diabetes mellitus. Therefore, Dona® can be taken by patients with diabetes mellitus. Dmitry, please comment.

1. Dmitry Veremeenko

   The effect on sugar levels is not the cause of death in people with diabetes, and therefore cannot be a guarantee of safety in diabetes.

Alexander

Hello Dmitry! Here is a link to a video clip of the “live healthy” program, where it is stated that chondroprotectors, which include glucosamine, are simply useless means whose effect has not been proven. You can comment on these statements osteohondrozinfo.com/preparaty/rumalon-i-alflutop

1. Dmitry Veremeenko

   Correctly stated in relation to the joints. Proven to prolong life.

Yuri

Dmitry, are you against glucosamine hydrochloride?

1. Dmitry Veremeenko

   Do not mind. Just glucosamine is much more effective.

   1. Yuri

      Yes, it looks like hydrochloride can be more considered as a raw material for the production of HS.

Yuri

Dmitry, you mentioned that it is undesirable to mix mitohormetins. Is it possible in this case to take glucosamine sulfate and eat broccoli?

1. Dmitry Veremeenko

Alexander

Good afternoon Dmitry. Earlier, on 12/16/2018, I sent you a link where Malysheva's kmn (the "live healthy" program) claims that a double-blind study has proven that Glucosamine does not cure arthritis. My personal experience of using glucosamine with chondoitin (though only on me and two people close to me, one of which my wife crawled to the toilet on her knees for back pain and was afraid to cough so as not to cause pain, after a day of using glucosamine with chondroitin, I got to my feet and began to walk, the pain went away) showed something that magically removes back pain, I saw such a miracle for the first time and experienced for myself what kind of diagnosis there was not clear acute inflammation, but the more powerless the doctor, the more he invents diagnoses, and also spices up Latin to maintain his authority. Now, in our regional center, doctors in this case are already prescribing glucosamine with chondroitin for back pain.
The question is, is there any research that is better for pain in the back, joints, glucosamine alone or together with chondroitin

1. Dmitry Veremeenko

Yuri

Found this warning about glucosamine: youtube.com/watch?v=yS8jL-0IWM8
Apparently it is necessary to develop a reduction in dosage or completely cancel, especially for prevention.

1. Dmitry Veremeenko
   1. Yuri

      yes, but she refers to research - you listen

      1. Yuri

         ncbi.nlm.nih.gov/pubmed/15149952
         Glucosamine-induced alterations of mitochondrial function in pancreatic beta-cells: possible role of protein glycosylation

         1. Yuri

            I must say, I popped 1.5 grams of glucosamine - and felt that I have a pancreas ... It often reminded me of itself before. What is it connected with? Maybe not with glucosamine, but hardly. Fact!

         2. Dmitry Veremeenko

            I know about it. In clinical studies, this appears at a dose of 3000 mg per day. We use 1500 mg per day. This has been discussed many times already. Any substance in a high dose is harmful. So sulforaphane from broccoli, if you eat a head of cabbage a day, it increases the mobility of transposons, which is onco dangerous. There is nothing useful that you can eat as much as you like.

   2. Yuri

      I understand, thanks. I think if you use it, then three times less than 1.5 g. In such a dose, GA will probably not show any effect at all?

Yuri

Perhaps it is worth using in a daily dose of 1.5 g, but fractionally?

1. Yuri

   I understand that glucose is also toxic to pancreatic beta cells. It's all about the dose at the moment, unless glucosamine accumulates in the pancreas to a significant extent. This issue needs to be studied. I don't think the danger should be ignored.

   1. Yuri

      Everything seems to be fine here: diabetes.diabetesjournals.org/content/55/11/3142

      1. Yuri

         The maximal concentrations of plasma glucosamine we observed after administration of the standard 500-mg oral dose (∼3 μmol/l) is ∼1,000- to 10,000-fold less than glucosamine concentrations used in human, animal, and cell-based studies reporting effects of glucosamine to cause insulin resistance and endothelial dysfunction (12,13,15,18,20,25,43). Moreover, the peak concentrations of glucosamine we observed after 500 mg oral dosing is also ∼1,000-fold below the Km of GLUT4 for glucosamine transport (44). Thus, based solely upon pharmacokinetic considerations and what is known about glucosamine distribution, it seems unlikely that oral glucosamine administration at standard doses would pose safety problems from either a metabolic or vascular perspective.

         1. Yuri

            Indeed, treatment of cells in vitro with glucosamine (1–10 mmol/l) causes both insulin resistance and endothelial cell dysfunction. More importantly, intravenous infusions of glucosamine that achieve plasma concentrations of 0.5–1.8 mmol/l in both animals and humans causes insulin resistance and endothelial dysfunction.

            Yes, such concentrations in the blood do not occur when taking pen os, but it is not entirely clear whether they allow the possibility of accumulation of glucosamine by beta cells; and I have no idea whether such a cumulation is possible. (The normal concentration of glucosamine in the blood is 5 µmol/L according to this article.)

         2. Dmitry Veremeenko

            That's why we use all the drugs in courses - glucosamine only in the months of anti-cancer

         3. Yuri

            CONCLUSION: NO DANGER IN GENERAL

   2. Dmitry Veremeenko

      We already studied this issue 3 years ago.

2. Dmitry Veremeenko

   Can be done in 2 doses

Alexander

1. Alexander
2. Dmitry Veremeenko

   Hyaluronic acid is never absorbed. The rest just don't work

Yuri

That's what's very interesting. The half-life of glucosamine is 68 hours!!!

1. Yuri

   I don't quite understand what this means. After all, glucosamine is a metabolite and is included in tissues, which means that the concept of the half-life for it is not entirely correct. On the other hand, such high concentrations of glucosamine in the blood apparently cannot be considered physiological and probably do not even occur during pathological processes and various kinds of physical overload. It follows from this that glucosamine, it can be assumed, acts as a medicine, showing exactly the medicinal effect - it is not fully included in metabolism, it is not integrated into tissues, but is deposited somewhere in its native state.

   1. Yuri

      It might be easier. They simply determine the half-life of radioactive labels. Naturally, glucosamine is built into the tissues and is not going to come out of there - which is natural. It is necessary to connect scientists pharmacologists to answer these questions.

      1. Yuri

         In general, even if 68 hours (3 days), then it's okay if you calculate the rolling dose.

Yuri

Further research on glucosamine is required. So far, it has been proven to cause insulin resistance when administered intravenously.

For example, the study below shows that in rats, glucosamine induces apoptosis of a small number of beta cells as early as day 28 of oral administration at a dose of 40 mg/kg per day. I do not know how exactly to translate this dose into a human one, but it will be about 3 g (40 * 70 kg).

researchgate.net/publication/305613061_HISTOLOGICAL_AND_BIOCHEMICAL_PANCREATIC_CHANGES_ASSOCIATED_WITH_LONG-TERM_ORAL_GLUCOSAMINE_THERAPY

1. Dmitry Veremeenko

   Doesn't call. Only in high doses

   1. Yuri

      Dimitri, good. You are probably sure of this, therefore you accept it yourself and can back it up with your own experience, in the sense of analyzes that indicate the absence of problems. What are these indicators, besides the level of glucose in the blood?

Sergey

Dmitry, during training with iron, pulled a ligament in the brachialis area, it does not hurt at rest, but with a bent tense arm, turning the hand left and right, the pain is somewhere in the biceps. can chondroguard help in healing? if not, what would you recommend?
With uv. Sergey.

1. Dmitry Veremeenko

   Can not. Rest 2-3 months - complete rest. Then contact the physical education dispensary to prescribe physiotherapy exercises. Without physiotherapy, recovery can take 1-2 years, or even never.

Katerina

Hello Dmitry,

if in the algorithm I enter the value of the HOMA IR index = 2, then with my BMI = 25.8 (in the table in the comments it is written that the value of the HOMA IR index is not taken into account when overweight), glucosamine is NOT prescribed.

If I set the HOMA IR index = 0 (do not enter the values), then glucosamine is prescribed.
Is this a bug or is it that the value of the HOMA IR index is not always taken into account?
Thank you.

1. Dmitry Veremeenko

   Zero is not required. Because that doesn't happen

   1. Katerina

      Still, it seems that in the algorithm, the prescription of glucosamine does not depend on body mass index.
      Despite elevated BMI, glucosamine is prescribed for normal HOMA IR and is not prescribed for elevated.

      Initially, I thought that before taking glucosamine, you need to lose weight to a normal BMI. And then take a blood test for insulin and glucose. Until then, just lose weight) Without glucosamine sulfate.
      I was right?

      1. Dmitry Veremeenko

         Because glucosamine sulfate prolongs life for those who are shortened by inflammatory processes (increased c-reactive protein). If the reactive protein is normal, then glucosamine sulfate is not prescribed. There are many more nuances - there are hundreds of them.

Larisa A.

Why can you take these 2 methohormetins: glucosamine + broccoli, but not glucosamine + metformin?

1. Dmitry Veremeenko

   Because broccoli and glucosamine are combined, there are examples. And how glucosamine and metofrmine will interact is unknown. And also sulforaphane, like mitohormetin, is not strong. And glucosamine and metofrmine are strong.

Ivan

Dmitry, please advise ... We have Pyritans Pride, American capsules - Glucosamine hydrochloride 1, 500 mg and Chondrotin sulfate + collogen - 1, 194 mg. Is this a good drug, can I buy and take it?

1. Dmitry Veremeenko

   Glucosamine hydrochloride is almost not bioavailable. Collagen is not absorbed at all

   1. Anna

      collagen is absorbed. I observe on my ligaments and skin. but I take it along with enzymes, proline and carnosine.

      1. Dmitry Veremeenko

Dmitry

Hello Dmitry!
I use option #8. Now there is a new recommendation for glucosamine. I would like to clarify. If my c-reactive protein is normal (during the year 0.3 - 0.6) and HOMA is less than 1.5 - (1.1), then it makes no sense to drink glucosamine? I just bought 3 cans of it, so I'm thinking what to do with them.

1. Dmitry Veremeenko

   Yes - no need. Wait for your inflammatory markers to rise
   Some drink glucose sulfate and think that it somehow helps them. But does it help, from what, does it harm? Glucosamine has been shown to prolong the lifespan of animals and has been associated with reduced mortality in humans. But how to make its use controlled?

   2009 University of North Carolina. Glucosamine (preferably sulfate) in human studies reduced the risk of death from colorectal and lung cancer, possibly by reducing inflammation (www.ncbi.nlm.nih.gov/pubmed/19423520). However, the exact mechanism has not been previously established. But, for example, in a study by the Fred Hutchinson Cancer Research Center, USA from 2015, it was found that glucose in a pilot study at a dosage of 1500 mg per day in an RCT in people with a body mass index of 25.0–32.5 kg/m2 for 28 days in aged 20-55 years reduced C-reactive protein by 23% (www.ncbi.nlm.nih.gov/pubmed/25719429) (www.ncbi.nlm.nih.gov/pubmed/22828954). That glucosamine can reduce cancer mortality by lowering C-reactive protein levels seems quite plausible, since, for example, an increase in C-reactive protein from 1 to 5 mg / l in blood tests linearly increases the risk of lung cancer by 3- 5 times based on VO2max (www.ncbi.nlm.nih.gov/pubmed/26008754).

   Therefore, if C-reactive protein is higher than 1 mg/l and there are no contraindications (HOMA-IR is not elevated in blood tests ncbi.nlm.nih.gov/pubmed/17570985, etc.) to the use of glucose sulfate, then therapy with this substance at a dosage 1500 mg per day may reduce cancer and all-cause mortality (academic.oup.com/ajcn/article/91/6/1791/4597416) by reducing inflammation, which is reflected in a decrease in the inflammatory marker C-reactive protein, expected to be approximately by 23%.

   It is important to note that glucosamine sulfate is likely to be able to extend the life of especially elderly mice and humans, which is quite valuable. So glucosamine extended the life of already very old mice (www.ncbi.nlm.nih.gov/pmc/articles/PMC3988823). And a 2010 study from the University of Washington, USA examined (among 77,673 participants) the use of 13 dietary supplements in the elderly, including glucosamine, in a 10-year study. Interestingly, neither Palmetto, nor β-carotene, nor flexo biloba, nor garlic, nor selenium, nor fish oil, nor other vitamins and minerals, nor multivitamin complexes involved in this study, reduced the mortality of older people, and some of them even raised. Fish oil increased the risk if it was used more than 3 times a week. And only glucosamine and chondroitin were associated with a reduction in overall mortality. The study involved Washington State residents aged 50 to 76 (www.ncbi.nlm.nih.gov/pubmed/20410091)

   1. Yuri

      Interestingly, due to what chondroitin reduced mortality?

      1. Dmitry Veremeenko

         Chondroitin did not reduce in animals at all. Most likely, it was simply used together with glucosamine - hence the connection

Dmitry Veremeenko

Its healing properties have not materialized in other studies.

Dmitry Veremeenko

All relevant information is in the section ANTI-AGING PLAN and AGING THERANOSTICS

Dmitry Veremeenko

However, glucosamine sulfate can increase intraocular pressure, so you should not use it with glaucoma.

ncbi.nlm.nih.gov/m/pubmed/27768119

1. Julia

   Dmitry, hello. This addition about the possibility of an increase in intraocular pressure in those taking glucosamine sulfate is very significant, as it seems to me. I saw him today quite by accident. I think if I had known about this earlier, I would not have risked taking glucosamine. I have had glaucoma for 4 years now and lately my blood pressure has become a little higher, although I am constantly dripping prescribed drops. I drink glucosamine according to the algorithm. I can’t say that it was he who caused the increase in IOP, but it’s probably impossible to exclude this either. Perhaps it would be more correct to add a question about the presence of glaucoma in the questions when filling out the algorithm? And do not recommend taking glucosamine to those who have it. You wrote "not worth it". Somehow it’s not very definite .. Still, is it possible or IMPOSSIBLE? Or reduce the dose? I'm having cancer month right now and I'm on 1500mg of glucosamine.

   1. Dmitry Veremeenko

      Glucosamine can sometimes increase intraocular pressure when used continuously. And it's reversible. Therefore, when using courses for a month with interruptions, such effects should not be expected.

Heat

8 healthy women over 50 who took 250mg Glucosamine sulfate once a day for 8 weeks showed a clear improvement in their skin.
ncbi.nlm.nih.gov/pubmed/28214837
karger.com/Article/FullText/450832

Here, apparently, the skin matrix has improved due to greater filling with hyaluronic acid.

1. Heat

Glucosamine is a substance produced by cartilage. The lack of this component is the cause of many diseases of the joints. Its use in formulations of dosage forms contributes to the effective treatment of diseases of the musculoskeletal system.

On the pharmaceutical market, the drug is available in several forms, each of which has a similar composition, but different auxiliary components.

Dosage forms:

• tablets;
• powder;
• solution.

Composition and dosage:

Tablets of 30, 60, 90 and 100 pieces in vials. 1 tablet contains:

• glucosamine sulfate - 750 mg;
• additional ingredients.

20 sachets in a pack. 1 sachet of solution powder contains:

• glucosamine sulfate - 1500 mg;
• other substances.

Glucosamine in ampoules for intramuscular injection (2 ml each):

• active substance - 400 mg
• auxiliary components.

Pre-dilute with the supplied solvent (1 ml ampoules).

Pharmacological properties

Glucosamine is designed to restore the structure of cartilage tissue. It significantly slows down the processes of destruction of the joints and prevents the development of arthrosis, eliminating the accompanying pain syndromes and increasing mobility.

The drug performs the following functions:

• stimulates metabolic processes;
• fills the natural need for the content of the substance;
• provides joint permeability;
• suspends destructive processes;
• normalizes the amount of calcium in bone tissues.

Instructions for use

Treatment of articular pathologies in adults with Glucosamine is mainly done orally in the form of powder or tablets, the dosage of which is determined by the doctor.

Scheme for taking the powder form:

• 1 sachet per day (dilute in a glass of water);
• take with meals;
• duration - up to 10 weeks (depending on the stage of the disease).

Pill system:

• 1 per day, with a glass of water;
• duration - 6 months.

The effect after taking the remedy is noticeable after 2 weeks, then the positive result is enhanced.

Indications for appointment

Glucosamine is a drug for the treatment of diseases of the joints and spine. It is prescribed in complex therapy for the following pathologies:

• osteochondrosis;
• osteoarthritis;
• periarthritis;
• trauma;
• progressive spondylosis.

The use of this drug allows you to eliminate the feeling of stiffness in the joints, inflammation, and relieve pain. It is recommended to be taken by people who are involved in heavy sports. As a prophylaxis, the drug is indicated for people over 55 years of age. Its intake significantly reduces the load on the joints, improves their mobility, and reduces the risk of developing articular pathologies.

Glucosamine for osteochondrosis

The effect of the drug in osteochondrosis of the spine is quite large: correction of metabolic processes in cartilage tissue, reduction of the destruction process, stimulation of metabolism, restoration of the previous functions of the joints.

Since the disease begins with pathological changes in the intervertebral cartilage, the use of Glucosamine in the treatment contributes to the complete elimination of the main cause of the problem.

This drug is part of a complex therapy aimed at a speedy recovery.

Contraindications

For the treatment of joints and to eliminate problems with the spine, preparations containing glucosamine chondroitin are used. Like any drug, this drug has contraindications, among which are:

• period of pregnancy and lactation;
• violations of the kidneys;
• children under 15 years of age;
• people who are highly sensitive to the components of the drug.

Side effects

Basically, the drug does not have complex consequences, but in some cases there are:

• pain syndromes in the area of ​​the obvious process;
• stool changes;
• bouts of flatulence;
• frequent headaches;
• skin rashes.

When such negative reactions of the body appear, it is recommended to immediately seek help from a specialist.

Interaction with other drugs

Glucosamine performs the following actions when combined with various medications:

• can significantly enhance the absorption of tetracycline drugs by the intestines;
• reduces the absorption of antibiotics;
• enhances the analgesic and anti-inflammatory effects of some nonsteroidal drugs, but with simultaneous use;
• helps to reduce the negative effect of corticosteroids on cartilage tissue.

Price

Cheap analogues of Glucosamine

Glucosamine, like any other drug of this type, has cheaper analogues that contain the main component:

• Arthra tablets;
• Honda in capsules;
• Sinarta - powder for oral use;
• Glucosate - solution for injection.

The use of the above medications is possible only with the permission of the attending physician.

Glucosamine and Elbona - which is better?

Elbona - a modern drug designed for the regeneration of articular tissues. Its composition contains the base tool, which contributes to the rapid recovery process of existing damage. In addition, the drug is effectively used to relieve severe pain and eliminate inflammatory processes. With the constant use of Elbona, the amount of nonsteroidal drugs is noticeably reduced in patients.

The drug Elbon is prescribed for such pathologies:

• bouts of osteoarthritis;
• osteoarthritis therapy;
• problems with the spine;
• treatment of osteochondrosis.

It is used in complex therapy along with physiotherapy procedures and a proper nutrition system. The drug belongs to the high-price category, which makes it impossible to use it for a wide range of people. Glucosamine has the same properties, but what to choose in the treatment of joint diseases is up to the attending physician.

Dona or Glucosamine - which is more effective?

Dona is the main stimulator of cartilage regeneration, has strong analgesic and anti-inflammatory properties. The active substance glucosamine sulfate helps to replenish its deficiency in the body, thereby helping to restore joint tissue.

Dona applies:

• for the prevention of osteoarthritis;
• in the treatment of periarteritis of the scapula and shoulder, chondromalacia of the patella.

The drug is quickly absorbed by the intestines, easily penetrates into the cartilaginous tissues of the joints. The therapeutic effect lasts up to 8 weeks.

Dona is a more expensive drug, and therefore less accessible to purchase by representatives of different social groups. Dona is a structural analogue of Glucosamine, but has a higher cost.

Chondroxide or Glucosamine - what to choose for osteochondrosis?

The local drug Chondroskid has anti-inflammatory properties, has an analgesic effect, improves joint regeneration.

The active substance chondroitin sodium sulfate slows down the process of bone destruction, reduces calcium loss, and normalizes metabolic properties. Has anti-inflammatory action.

It is used to treat pain syndromes in cartilaginous tissues in osteochondrosis and osteoarthritis, to increase joint mobility.

Chondroxide is used:

• with degenerative pathologies of the spine and joints;
• with fractures;
• to eliminate the consequences of surgical interventions.

The drug has an extensive spectrum of action, is available for purchase to everyone. Chondroxide, as well as Glucosamine, has the ability to restore damaged cartilage tissue, but to improve the effect, doctors recommend combining both drugs.